Ted the interactions revealed by I-DIRT: anti-GBF1, -SLIRP,-CAD, -XPOT, and -HSP90 antibodies specifically co-immunoprecipitated NS5 (Fig. 3A), and anti-IPO4, -HSP27, -SERPINH1, -ZW10, -HSP90 , and -HSP70 antibodies similarly coimmunoprecipitated NS3 (Fig. 3B). Of the interactors tested, only HEATR2 yielded inconclusive results and thus could not be validated by this approach; however, we also not