Eptor complex that can be relieved by channel opening or relaxation of the LBD dimer interface to a desensitized state, in which agonist remains bound but the channel is closed (Sun et al., 2002; Sobolevsky et al., 2009) (Fig. 3). The receptor deactivates as the channel closes and the ligand fully unbinds, exiting the binding cleft. Positive AMPA receptor modulators bind at the LBD dimer interface