Ing affect actin dynamics and zymosan bioparticle phagocytosis. Live cell imaging demonstrated that G i and G are enriched with F-actin at cell membrane protrusions and phagocytic sites. Inhibiting G i nucleotide exchange, reducing Ric-8A expression, or inhibiting G signaling all substantially reduced phagocytosis. BMDM that lack G i2 or G i3 also had a reduced capacity to engulf zymosan. In contr