Ompared with glial cultures. Two RE1/NRSE-like sequences that contain key mismatches in the consensus sequences were identified at 989 and 427 and do not seem to act as silencers of the Grin2a gene. Thus, neuronal specificity for GluN2A expression seems to result from transcriptional activation selectively in neurons rather than by non-neuronal silencing. Furthermore, three regions were identified