Appear to be functionally similar. Hence, it seems that Cdc50 proteins function as chaperones responsible for the proper maturation of P4ATPases, rather than serving as translocases or symporters themselves. P2C-ATPase -subunits also modulate intrinsic kinetic parameters of the Na /K pump (Geering, 2008), and a similar role for Cdc50-like proteins in P4-ATPases cannot be excluded. In sum, the comb