D presentation--Antigen processing and presentation through the major histocompatibility complex (MHC) is a critical step in initiating effective cell-mediated adaptive immune response against pathogens. Downregulation of the cell surface MHC class I molecules is a key viral immune evasion strategy. KSHV encodes two zinc finger membrane proteins MIR1 and MIR2 (also called K3 and K5) which are E3 u