Ved calciumsensing protein that antagonizes some proteinases and modulates stability of regulatory proteins (1, 16, 25). CaM binds its targets in a calcium-bound (holoCaM) or calcium-free (apopCaM) form, and thus its interactions with partners may be Ca2 dependent or Ca2 independent (25). Many CaM binding proteins harbor recognition motifs characterized by a basic amphipathic helix, moderate to hi