Efense mechanism against virus attack is to deregulate the complement system. Like many other viruses, KSHV also interferes with complement and this is targeted by the KSHV-encoded ORF4 also called complement control protein (KCP) which has homology to humanNIH-PA Author Manuscript NIH-PA Author Manuscript NIH-PA Author ManuscriptAdv Virus Res. Author manuscript; available in PMC 2011 July 23.Cai