Tained after transient transfection of ApoE isoforms provided evidence of association between ApoE isoforms and RelA (Fig. 7B). Thus, although RelA coimmunoprecipitated with both ApoE3 and ApoE4, only ApoE4 led to the translocation of RelA into the nucleus. We also evaluated the interaction of ApoE and the putative RelA-binding region, acgtggaaattccca, on the SirT1 promoter by SPR. Neither ApoE is