N animal model of pneumonia. We hypothesized that during P. aeruginosa infection adenoviral CaM gene transfer would counteract actions of the E3 ligase FBXL2, thereby preserving CCT and surfactant levels. In mice, the PA103 pathogen decreased CCT levels (Fig. 7A and B), thereby reducing surfactant phosphatidylcholine (Fig. 7C) needed to stabilize lung function (39). Mice infected with PA103 also e