Ate proliferation; uPAR expression also confers resistance to caspase-mediated apoptosis and anoikis (104, 105). Numerous studies have documented that strategies to block uPAR expression are associated with decreased angiogenesis and tumor growth and metastasis (85, 103, 106). In contrast, uPAR has been shown to promote angiogenesis in the eye (107). In the UUO model of chronic kidney disease uPAR