Channels at glutamatergic synapses (Maximov Bezprozvanny 2002). In the postsynaptic compartment, NL1 may bind through cytoplasmic PDZ-domain interactions to PSD95 and thereby recruit NMDA-Rs to glutamatergic synapses (Irie et al. 1997). Although the relevance of PSD95 or other scaffolding molecules for the NL1-mediated synaptic recruitment of NMDA-Rs remains to be tested, a conceptually similar