Tudied member of the Lrp family (241) or the FFRP (feast/famine regulatory protein) family (242). Because many reviews (6, 241?244) dealing with Lrp can be found in the literature, we only summarize here. Lrp is a small protein ( 19 kDa) (244). It consists of an N-terminal DNA binding domain, harboring the canonical helix-turnhelix motif, connected with a flexible hinge to a C-terminal ligand bind
Ndividually in "live-gate" mode. The results were expressed as relative fluorescence intensity (RFI) calculated as geometric mean fluorescence intensity (GFI) of stimulated cells/GFI of control (unstimulated) cells. The experiment was repeated three times and the expression levels were expressed as the mean SEM. Statistical significance was determined using the Student's t test.RESULTS Membrane Ru
Ndividually in "live-gate" mode. The results were expressed as relative fluorescence intensity (RFI) calculated as geometric mean fluorescence intensity (GFI) of stimulated cells/GFI of control (unstimulated) cells. The experiment was repeated three times and the expression levels were expressed as the mean SEM. Statistical significance was determined using the Student's t test.RESULTS Membrane Ru
Efense mechanism against virus attack is to deregulate the complement system. Like many other viruses, KSHV also interferes with complement and this is targeted by the KSHV-encoded ORF4 also called complement control protein (KCP) which has homology to humanNIH-PA Author Manuscript NIH-PA Author Manuscript NIH-PA Author ManuscriptAdv Virus Res. Author manuscript; available in PMC 2011 July 23.Cai
De (LY404187), N-(2-(4-(thiophen3-yl)phenyl)propyl)propane-2-sulfonamide (LY392098), (R)2-(4-(3,5-difluorobenzoylamino)phenyl)-1-(2-propanesulfonamido)-propane (LY450108), LY451395, and LY503430] (Ito et al., 1990; Copani et al., 1992; Arai et al., 1996, 2000; Baumbarger et al., 2001a,b). Although positive AMPA receptor modulators fall into three structural classes, the most important difference b
Ple Preparation. Intra-assay precision was defined as the peptide concentration CV for the three runs on the same day and then averaged across the 3 days. The inter-assay precision was defined as the peptide concentration CV for the same run on 3 days (e.g. Day 1, Run 1; Day 2, Run 1; and Day 3, Run 1) and then averaged across the 3 runs. This experiment was performed for 6 individual fresh whole-
Ple Preparation. Intra-assay precision was defined as the peptide concentration CV for the three runs on the same day and then averaged across the 3 days. The inter-assay precision was defined as the peptide concentration CV for the same run on 3 days (e.g. Day 1, Run 1; Day 2, Run 1; and Day 3, Run 1) and then averaged across the 3 runs. This experiment was performed for 6 individual fresh whole-
Ple Preparation. Intra-assay precision was defined as the peptide concentration CV for the three runs on the same day and then averaged across the 3 days. The inter-assay precision was defined as the peptide concentration CV for the same run on 3 days (e.g. Day 1, Run 1; Day 2, Run 1; and Day 3, Run 1) and then averaged across the 3 runs. This experiment was performed for 6 individual fresh whole-