To demyelination.8,9 The features of axonal damage in MS, however, were similar to those detected in other neurological diseases lacking demyelination, such as amyotrophic lateral sclerosis (ALS),?2011 Mount Sinai School of Medicine Address Correspondence to: Patrizia Casaccia, Departments of Neuroscience and Genetics and Genomics Mount Sinai School of Medicine New York, NY, patrizia.casaccia@mssm