In IL-23R is associated with SSc and ATA positivity. IL-23R variant rs11209026*GG (Arg381 Gln variant) has association with ATA positivity and rs11465804*TT is associated with dcSSc and ATA positivity. The major alleles rs11209026*G and 11465804*T were decreased in patients with PAH, suggesting that the major allele is protective against PAH (28).iL-2/iL-12 Genetic SusceptibilityIntegrin M (ITGAM)