The mRNA-destabilizing machinery that binds to AU-rich elements (54, 55). TTP is also known to be hyper-phosphorylated by p38 MAPK, which is associated with a decrease in the RNA-binding capacity of this protein and results in the subsequent inhibition of RNA degradation (55, 56). In addition, as a negative feedback mechanism TTP phosphorylation was shown to be regulated by protein phosphatase 2A