R (FGF-2), a heparin-binding peptide, that stimulates pathologic angiogenesis. However, FGF-2 expression alone is neither necessary nor sufficient for CNV development [71, 72]. Transforming growth factor-beta (TGF-) is another important factor secreted by RPE during active CNV phase [73]; since it is a potent inducer of extracellular matrix synthesis, reliably it limits the extent of neovascular c