And growth factors (Antonetti et al., 1999; Harhaj et al., 2006; Joussen et al., 2001). Molecular alterations, such as in proteins of the tight junction complex, also have been demonstrated to play a significant role in the diabetes-induced increase in capillary permeability (Erickson et al., 2007). VEGF is known to be a key molecule leading to retinal permeability in diabetes and other retinal di