Omplement components on their surfaces [96]. Thus, binding of this major alternative complement pathway inhibitor is related to serum resistance in Leptospira spirochetes. Interestingly, FH binding was shown to be dependent upon Lig proteins [97]. The multifunctional LigB protein also binds to C3b and C4b and interferes with complement activation [98]. Lsa30, a novel leptospiral adhesion protein,