Neuropathic pain depend on Toll/IL-1 receptorNEUROIMMUNOPHARMACOLOGIC IMPLICATIONS FOR OPIOID ANALGESIAsignaling; rather, they are complemented and possibly facilitated by this system. Therefore, significant attention should be paid to the role of Toll/IL-1 receptor signaling when examining opioid pharmacodynamics. C. What Are the Opportunities Provided by Pharmacological Targeting of Central Immu