Gh both fly strains express equivalent levels of Go (Fig. 3F, input). As noted above, Nishimoto et al. (1993) identified a candidate Go-binding domain within the cytoplasmic domain of human APP695 (His657-Lys676) that was required for APP-Go interactions in reconstituted liposomes (Okamoto et al., 1995). To determine whether the conserved Go-binding domain is required for APPL o interactions in th