E used as controls. Oligonucleotides were delivered by standard lipofection and 48 h after transfection, subunit c isoforms silencing efficiency was estimated by qRT-PCR. The silencing of individual subunit c isoforms resulted in a variable reduction of the corresponding mRNA levels ranging from 80 to 95 of scrambled controls (Figure 1B). The silencing of P1 and P2 was also associated with a mode