Oss five lifecycle stages and identifications of host proteins associated with first-stage larvae (microfilariae) in the blood. Applying intensity-based quantification, we determined the abundance of 302 unique excretory-secretory proteins, of which 64.6 were present in quantifiable amounts only from gravid adult female nematodes. This lifecycle stage, together with immature microfilariae, releas

N, and nebulin molecules). A PDZ domain typically consists of 80 to 100 residues forming six -strands and two -helices. The carboxyl-terminal tail of the 7TMR is believed to interact with an elongated surface groove that is situated between the second -strand and the second -helix in an antiparallel manner. The functional implications of such interactions are as diverse as the PDZ domain-containin

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