N, and nebulin molecules). A PDZ domain typically consists of 80 to 100 residues forming six -strands and two -helices. The carboxyl-terminal tail of the 7TMR is believed to interact with an elongated surface groove that is situated between the second -strand and the second -helix in an antiparallel manner. The functional implications of such interactions are as diverse as the PDZ domain-containin
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