Receptor modulation and prognostic significance in primary breast cancer. J Natl Cancer Inst 2010, 102:54-68. 8. Ramadoss P, Marcus C, Perdew GH: Role of the aryl hydrocarbon receptor in drug metabolism. Expert Opin Drug Metab Toxicol 2005, 1:9-21. 9. Osborne CK, Schiff R, Fuqua SA, Shou J: Estrogen receptor: current understanding of its activation and modulation. Clin Cancer Res 2001, 7:4338s-434

Mpared GFP expression of parental and J-Lat shER cells using fluorescence activated cell sorting (FACS). As expected, no GFP-expressing cells could be detected in untreated cells (Figures 6C-6F, mock). About 20 of cells turned GFP-positive in TNF--treated J-Lat 9.2 cells (Figure 6C, TNF-). Importantly, the inhibition of PP5 transcription synergized with TNF- to increase further the number of GFP-

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Etabolic control marker (Table 6). The best cutoff for predicting cardiovascular events (86.6) identified 80 of patients who suffered a cardiovascular event and was associated with a risk of events 10.7 times higher over time. It was lower than the value commonly used to predict high risk of CAD in general population (400). A CS of 0, as a low risk marker, missed one patient with significant CAD

Etabolic control marker (Table 6). The best cutoff for predicting cardiovascular events (86.6) identified 80 of patients who suffered a cardiovascular event and was associated with a risk of events 10.7 times higher over time. It was lower than the value commonly used to predict high risk of CAD in general population (400). A CS of 0, as a low risk marker, missed one patient with significant CAD

Ause mortality, n ( ) Cardiovascular death Non-cardiovascular death CVEV and CS = 0, n ( ) CVEV and CS

Ause mortality, n ( ) Cardiovascular death Non-cardiovascular death CVEV and CS = 0, n ( ) CVEV and CS

R JS, Kietz S, Wimalasena J, Gustafsson JA: Estrogen receptor beta inhibits 17beta-estradiol-stimulated proliferation of the breast cancer cell line T47D. Proc Natl Acad Sci USA 2004, 101:1566-1571. 2. Liu MM, Albanese C, Anderson CM, Hilty K, Webb P, Uht RM, Price RH Jr, Pestell RG, Kushner PJ: Opposing action of estrogen receptors alpha and beta on cyclin D1 gene expression. J Biol Chem 2002, 27