B, and replotted the data as a function of A=IC50 , the data did lie on a universal curve (Figure 7A). From the analysis of these data we could not determine the number of gp41 bridging the virus and target cell at the start of the experiment, but the analysis indicated that these bonds are few in number and under considerably more strain then if there were a large number of attachments in the con
B, and replotted the data as a function of A=IC50 , the data did lie on a universal curve (Figure 7A). From the analysis of these data we could not determine the number of gp41 bridging the virus and target cell at the start of the experiment, but the analysis indicated that these bonds are few in number and under considerably more strain then if there were a large number of attachments in the con
Becomes independent of N. We first calculate pb in this limit when there is a uniform distribution of gp41 trimers bridging the virus and target cell and pb is independent of N. When we analyze neutralization experiments we will consider how pb depends on N when N is small. To obtain an expression for pb , we assume the following: 1. In the absence of mAb or Fab bound to the MPER, fusion is irreve
F (t)=E0 (0) ??For any single epitope, the probability of it fusing with the target cell it is bound to before it is disabled by a bound antibody is equal to f (?). The probability of this fusion being prevented by an antibody is pb 1{f (?) ??The probability pb of disabling a gp41 trimer in the pre-hairpin intermediate may depend on both A, the mAb concentration and on N, the number of gp41 trime
F (t)=E0 (0) ??For any single epitope, the probability of it fusing with the target cell it is bound to before it is disabled by a bound antibody is equal to f (?). The probability of this fusion being prevented by an antibody is pb 1{f (?) ??The probability pb of disabling a gp41 trimer in the pre-hairpin intermediate may depend on both A, the mAb concentration and on N, the number of gp41 trime
L V3 variants of 20 virus clones. The position mean (red line) is the error rate estimated at each position of V3 by comparing the UDS reads to the Sanger sequences of 20 clones. The shaded regions represent the 99 confidence interval of global (blue) and position (red) mean error rates.compare the systems. The mean frequency of V3 variant artifacts found with the 454 GS-Junior was 0.018 [exact
Ic? Findings from a population based study in Karachi, Pakistan. BMC Infect. Dis., 9, 38. http://dx.doi.org/10.1186/1471-2334-9-38 Fox, M. P., Mazimba, A., Seidenberg, P., Crooks, D., Sikateyo, B., Rosen, S. (2010). Barriers to initiation of antiretroviral treatment in rural and urban areas of Zambia: a cross-sectional study of cost, stigma, and perceptions about ART. J. Int. AIDS Soc., 13, 8. h
Ic? Findings from a population based study in Karachi, Pakistan. BMC Infect. Dis., 9, 38. http://dx.doi.org/10.1186/1471-2334-9-38 Fox, M. P., Mazimba, A., Seidenberg, P., Crooks, D., Sikateyo, B., Rosen, S. (2010). Barriers to initiation of antiretroviral treatment in rural and urban areas of Zambia: a cross-sectional study of cost, stigma, and perceptions about ART. J. Int. AIDS Soc., 13, 8. h