Ptic disruption evident in the AD1 cohort via increased concentrations of soluble A or in-creased insoluble A plaque burden. However, whether the effects of APOE*4 on enhanced synaptic binding of toxic soluble A species account for the alterations we observed in the synaptic proteome cannot be concluded from the current experiment. Network Topology as an Indicator of Protein Homeostasis-- When the
Co-2 cells or islets of undifferentiated Caco-2 cells (332, 333). Listeria. Listeria monocytogenes is a ubiquitous, Gram-positive bacterium that thrives in diverse environments such as soil, water, various food products, human beings, and animals (300, 301, 334). The disease caused by this bacterium, listeriosis, is acquiredby ingesting contaminated food products and mainly affects immunocompromis
Fact that these effectors of the innate immune system are highly up-regulated at the transcription level after immune challenge. Other highly induced proteins include heat shock protein (HSP) 25.4's, lipases, esterases, peptidases, lipidbinding proteins, and some hypothetical proteins. While some of them mediate metabolic changes in response to the stressMolecular Cellular Proteomics 15.Proteomi
Fact that these effectors of the innate immune system are highly up-regulated at the transcription level after immune challenge. Other highly induced proteins include heat shock protein (HSP) 25.4's, lipases, esterases, peptidases, lipidbinding proteins, and some hypothetical proteins. While some of them mediate metabolic changes in response to the stressMolecular Cellular Proteomics 15.Proteomi
H these results might suggest a specific nature of Nup124p's FXFG-domain requirement, it is possible that Nup124p interacts in a similar manner with proteins, such as transport factors, other nucleoporins, none of which are essential for viability and therefore unaffected by overexpression of the FXFG domain. The growth rate is not affected upon overexpressing these domains, indicating that essent
Lar Cellular Proteomics 14: 10.1074/mcp.O115.049957, 3094?104, 2015. The dried blood spot (DBS)1 methodology provides several advantages over traditional plasma or serum samples throughout the entire pre-analytical workflow including sample collection, transportation, and storage (1, 2) These blood samples are typically generated using a small sterile lancet to prick the skin and then spotting a
Ia neuroligins. Cell. 2004; 119:1013?6. [PubMed: 15620359] Grunwald IC, Korte M, Wolfer D, Wilkinson GA, Unsicker K, et al. Kinase-independent requirement of EphB2 receptors in hippocampal synaptic plasticity. Neuron. 2001; 32:1027?0. [PubMed: 11754835] Haase G, Dessaud E, Garces A, de Bovis B, Birling M, et al. GDNF acts through PEA3 to regulate cell body positioning and muscle innervation of spe
Ns of the microtubule. There is another level of complication with regard to the issue of microtubule cold-stability. As defined above, the cold-stable fraction is that fraction of the microtubule mass that is resistant to depolymerization by cold in biochemical preparations. However, the same rules about microtubule cold stability do not apply to cells that are intact. When intact cells are expos