Y in the IOs. The expression levels of 257 proteins (12.4 ) were either down- or up-regulated (122 and 135 proteins, respectively) in both IOs and OCs (relative to OPs), and 48 (29 and 19 proteins) showed a reversed direction of change between IOs and OCs (supplemental Fig. S5B). The most significant molecular and cellular functions of the 492 down-regulated proteins in the OCs relative to OPs inv