Tion-inducing activities of ESR1 [1,2]. Unraveling the precise role of DC-SCRIPT in the complex genomic and non-genomic interplay between ESR1, ESR2, and their isoforms [21-23] might turn out to be rewarding for elucidating the `yin-yang' role of these factors in breast cancer. As DC-SCRIPT can inhibit ERa and PR activity, a second aim of the study was to address whether DCSCRIPT affects the respo