Formed five independent experiments and demonstrated that NFAT5 siRNA (NFAT5#1) significantly inhibited (p , 0.02) NFAT5 mRNA expression in MDM cells (Figure 6A). We note that the second specific NFAT5 siRNA behaved identically in two experiments where it was tested (unpublished data). We also investigated the impact of siRNA directed against NFAT5 upon NFAT5 protein production using intracellular