Everse transcriptase inhibitors (NNRTIs). RMP decreases the plasma concentration of protease inhibitors (PIs) to subtherapeutic levels when the PIs are given at standard doses [15?8]. Coadministration of the PI at higher doses or super-boosting the PI with higher doses of ritonavir (RTV, or r) may result in unacceptably high rates of liver toxicity [18?1]. To complicate things further, risk of tox