Each agent. Furthermore, therapeutic monitoring of saquinavir may help to optimize regimes for the coadministrationEffect of saquinavir on rifabutin pharmacokineticsThe mean ( CV) AUC(0,24 h), Cmax and C24 for rifabutin when administered alone were 3007 ng mlx1 h (28.0 ), 308 ng mlx1 (32.8 ) and 46.4 ng mlx1 (26.2 ), respectively. When coadministered with saquinavir the mean ( CV) AUC(0,24 h), Cma