E 2 cm ESR1-positive and ESR2-low, tumor size >2 cm ESR1-positive or ESR2-low or both, tumor size 2 cm ESR1-positive or ESR2-low or both, tumor size >2 cmaDisease-free survival Number 837 199 638 312 525 410 410 378 459 306 332 175 218 147 181 334 386 HR 95 CI P value 0.001 0.59 0.001 0.19 0.007 0.003 0.43 0.001 0.31 0.001 0.34 0.84 0.005 0.66 0.25 0.82 0.73 0.93 0.94 0.76 1.17 0.79 0.68 0.90 0