The mRNA-destabilizing machinery that binds to AU-rich elements (54, 55). TTP is also known to be hyper-phosphorylated by p38 MAPK, which is associated with a decrease in the RNA-binding capacity of this protein and results in the subsequent inhibition of RNA degradation (55, 56). In addition, as a negative feedback mechanism TTP phosphorylation was shown to be regulated by protein phosphatase 2A

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A and adjusting for differences based on sex, we no longer see this correlation. In addition, in this study, HCV coinfection is not associated with loss of elite controller status. Taken together, this suggests that HCV coinfection does not directly affect HIV replication dynamics or natural history, but that it may act synergistically with HIV to produce a greater number of associated complicatio