Nal peptide (SignalP 3.0), transmembrane domains (transmembrane helices by hidden Markov model), and PEXEL motif. The transcript levels of cognate genes were derived from the DeRisi and co-worker (15) transcriptome data, orthologs were from the Plasmodium database (16), and genome-wide polymorphism data were obtained from a study by Mu et al. (17). Protein function was assigned based on published

Kinetic formulation of the effect stands ready to be integrated into the expanding thermodynamic description of the GPCR system at large (Kenakin, 2010). From a practical point of view, the availability of naturally occurring pluridimensional effects suggests it should be possible to fine-tune the therapeutic action of a GPCR drug beyond the simple margins traditionally dictated by the target's ti

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