Fected CD4+ resting T cells, constitutes the HAART-persistent latent reservoir. Most cells in this silent reservoir have long half lives [6, 7] and are hidden from immune surveillance which permits them to remain as a stable source for de novo viral production upon reactivation. One strategy for eradication of this reservoir rests upon the premise that cellular activation with concomitant upregula

Quency at baseline (medians of 43 and 134 observed doses in those reporting to the OTP,5 days and 5 days per week, respectively). Fifty six percent (IQR 20 ?9 ) of expected observed doses were actually observed. Drop-out from the OTP or ART discontinuation accounted for a substantial proportion of non-observed doses. For example, when considering only the weeks in which DAART participants were re

Quency at baseline (medians of 43 and 134 observed doses in those reporting to the OTP,5 days and 5 days per week, respectively). Fifty six percent (IQR 20 ?9 ) of expected observed doses were actually observed. Drop-out from the OTP or ART discontinuation accounted for a substantial proportion of non-observed doses. For example, when considering only the weeks in which DAART participants were re

Ollowing the intervention phase) there were no significant differences between DAART and SAT in the proportions with HIV RNA ,50 copies/mL (0.47 vs. 0.33; difference, 0.13; 95 CI, 20.08 to 0.34), the proportions with HIV RNA ,400 copies/mL (0.51 vs. 0.44; difference, 0.08; 95 CI, 20.14 to 0.29), average change in HIV RNA from baseline (21.04 vs. 21.33 log10 copies/mL; difference, 0.29; 95 CI, 2

Ues for the amount of antibody bound were obtained by subtracting binding measured in the absence of sCD4 from the binding measured at each time point after the sCD4 pulse.buffer, cells were incubated at room temperature for 45 minutes in FACS buffer containing a phycoerythrin-conjugated goat antihuman IgG antibody (Sigma) and an anti-CD4 fluoresceinconjugated antibody (OKT4, eBioscience) to measu

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