Ator of nuclear receptors, we explored its prognostic value in relation to estrogen-receptor-a (ESR1) and -b (ESR2) and evaluated its predictive value for response to tamoxifen treatment. Methods: DC-SCRIPT mRNA levels were measured by real-time PCR in 1,505 primary invasive breast cancers and associated with outcome (disease-free survival (DFS), metastasis-free survival (MFS) and overall survival

Either ESR1-positive and/or ESR2-low pT1 tumors.Introduction Estrogens influence the aggressiveness of breast cancer through their cognate nuclear receptors. In particular, the estrogen receptor-alpha (ERa) (ESR1) - present in tumor cells of about 70 to 75 of all breast tumors is considered crucial because of its proliferationinducing actions and for that reason is an important target for therap

D if the HSV-2 diagnosis occurred at or after HIV seroconversion, and ulcers were excluded if they occurred at or after HIV seroconversion. We estimated the proportion of participants with 1 ulcer AE classified as Gradeor above (i.e., moderate, severe, or potentially life-threatening), 1 STI examination during which a perianal ulcer was detected, and 1 STI examination during which a groin ulcer

Nd multivariable analysis higher DC-SCRIPT levels were associated with a favorable outcome for both the entire cohort and patients with lymph node-negative (LNN) disease that did not receive adjuvant therapy (DFS, MFS and OS; all, P

Arned groups. This makes intuitive sense, as negatively framed warnings involve emphasizing the loss of a desired opportunity or reward if they are becoming dishonest i.e., becoming disqualified from getting a monetary reward. In contrast, positively framed warnings involve emphasizing the reward the individual will get really should they be truthful. The authors reasoned that since the negatively

Aseline by age group at enrollment, while Figure 1b shows HSV-2 incidence during follow-up by age group at enrollment. HSV-2, herpes simplex virus type 2. doi:10.1371/journal.pone.0091513.gDiscussionIn this analysis of participants in the iPrEx trial of daily oral FTC/TDF PrEP, we found no association between FTC/TDF and incidence of HSV-2 infection, even after accounting for actual use of FTC/TDF

Atinger H, Carpenter CB, et al. (2000) Protection of macaques against vaginal transmission of a pathogenic HIV-1/SIV chimeric virus by passive infusion of neutralizing antibodies. Nat Med 6: 207?10. 24. Bohnhorst J? Bj gan MB, Thoen JE, Natvig JB, Thompson KM (2001) Bm1Bm5 classification of peripheral blood B cells reveals circulating germinal center founder cells in healthy individuals and distur

Ly at doses of 5 ?108 pfu each. Clinical monitoring for symptoms took place for one hour, and symptom diaries were kept for one week following each immunization. All toxicities noted during the study were classified by the DAIDS Toxicity Table for Grading Severity of Adult Adverse Experiences? dated August, 1992, and a protocol specific Supplemental Toxicity Table for reactogenicity occurring with