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Ns dormant. In contrast, we demonstrated that TI could be counteracted by specific inhibition of the upstream transcription or by cooperative activation of transcription initiation and elongation from the 5'LTR by the viral and host TFs. In the latter scenario, we envision that RNAPII initiating from the viral promoter competes successfully with the RNAPII that is elongating through the 5'LTR. Bec
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Ed cells. Furthermore, TNF- stimulation led to the appearance of Sp1 and initiating RNAPII on the 5'LTR and additional enrichments of initiating and elongating RNAPII on the 3'LTR. These effects are most likely achieved through the activation of NF-B, which stimulates several steps of viral transcription including the PIC formation, transcription initiation and transcription elongation. Thus, our
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Ed cells. Furthermore, TNF- stimulation led to the appearance of Sp1 and initiating RNAPII on the 5'LTR and additional enrichments of initiating and elongating RNAPII on the 3'LTR. These effects are most likely achieved through the activation of NF-B, which stimulates several steps of viral transcription including the PIC formation, transcription initiation and transcription elongation. Thus, our
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E in PMC 2016 November 29.Extended Data TableVRC01 and 3BNC117 antibody concentrations in the plasma of macaques after a single administration of the indicated MAbs.3BNC117 conc (g/ml) DFVB 0.1 0.0 1.0 1.4 2.0 3.0 3.6 4.0 4.4 5.4 6.4 7.4 8.0 8.4 9.0 9.4 10.4 0.22 11.0 11.4 12.1 12.6 13.6 14.0 14.6 15.0 15.4 16.0 16.4 0.1 0.3 0.3 0.2 0.2 0.1 0.1 0.1 0.1 0.7 0.6 0.5 0.4 0.4 0.3 0.3 0.2 0.1 0.1 0.1 0
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The Robertson Foundation and HHMI.Nature. Author manuscript; available in PMC 2016 November 29.The plasma concentrations of the infused 10-1074 and VRC01-LS were measured longitudinally in the indicated animals.VRC01-LS conc (g/ml)DFXT14.12.12.11.10.9.9.7.6.5.5.4.3.2.1.33 0.10 23.0 0.9.8.8.7.6.4.4.4.2.1.1.1.Wks14.14.15.15.16.16.17.17.18.18.19.19.20.20.DFDP4.3.1.1.1.1.0.0.0.0.0.0.26.3 0.3.1.1.0.03P
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M et al.Author ManuscriptAuthor ManuscriptAuthor ManuscriptGautam et al.DFZWPage13.11.11.10.9.6.2.2.1.1.0.0.0.DFZV16.13.14.12.12.11.10.10.0.ACKNOWLEDGEMENTSWe thank R. Plishka, A. Peach and T. Lewis for determining plasma viral RNA loads and K. Rice, R. Engel, R. Petros and S. Fong for diligently assisting in the maintenance of animals and assisting with procedures. We also thank R. Schwartz, Vacc
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M et al.Author ManuscriptAuthor ManuscriptAuthor ManuscriptGautam et al.DFZWPage13.11.11.10.9.6.2.2.1.1.0.0.0.DFZV16.13.14.12.12.11.10.10.0.ACKNOWLEDGEMENTSWe thank R. Plishka, A. Peach and T. Lewis for determining plasma viral RNA loads and K. Rice, R. Engel, R. Petros and S. Fong for diligently assisting in the maintenance of animals and assisting with procedures. We also thank R. Schwartz, Vacc
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Y i is given by:Verguet Cost Effectiveness and Resource Allocation 2013, 11:1 http://www.resource-allocation.com/content/11/1/Page 3 ofTable 1 Cost parameters for the male circumcision interventionIntervention Initial investment per circumcision facility CF Initial training per circumciser CT Salary of each circumciser CC Salary of health care workers/counselors per circumciser Cost of supplies pe