To certain infections: 26 (n = 22) of Finnish patients with recurrent respiratory infections vs.14 (n = 10) of healthy controls (p = 0.048) had C4A deficiency. Not unexpectedly, 50 of the patients with C4A deficiency had MBL concentrations .1.5 mg/ml, the mean human MBL serum concentration but notably, more than one-third had very high MBL levels (.4 mg/ ml). Further clinical studies are requir
E trade-offs with regards to costs and performance in people living with HIV. The cost-effectiveness of novel diagnostic algorithms that incorporate these new tools alone or in combination with each other and with conventional diagnostic modalities is unknown. Prior studies have suggested that Xpert replacement of smear-microscopy is cost-effective for diagnosis of pulmonary TB in the general popu
E compared this rapid algorithm with current TB diagnostic approaches, which rely upon sputum examination by smear-microscopy or Xpert alone [15].NIH-PA Author Manuscript NIH-PA Author Manuscript NIH-PA Author ManuscriptMethodsEthics statement The study was approved by the institutional review board (IRB) at the Johns Hopkins University School of Medicine (Baltimore, Maryland, USA), as well as in