Ion sequencing platforms for determining HIV-1 coreceptor useSt hanie Raymond1,2,3, Florence Nicot3, Nicolas Jeanne3, Olivier Delfour3, Romain Carcenac3, Caroline Lefebvre3, Michelle Cazabat1,3, Karine Saun?,2,3, Pierre Delobel1,2,4 Jacques Izopet1,2,The coreceptor used by HIV-1 must be determined before a CCR5 antagonist, part of the arsenal of antiretroviral drugs, is prescribed because viruse
He expected values and the values obtained with both MiSeq ( = 1, p
Dons at each V3 position among the 20 virus clones (Fig. 1). We then attributed a weighted error rate to each position and used these rates to construct a sensitivity threshold matrix for each position of V3 to retain a minor virus variant harboring point mutations as authentic for a given number of reads with P