N of cRAI in the past three months being reported more frequently in the placebo arm (P = 0.01). Of the 1,383 participants who tested seronegative for HSV-2 at baseline, 36 (2.6 ) did not contribute person-time to incidence analyses because they were retrospectively found to be HIVinfected at baseline, tested seropositive for HSV-2 at the enrollment visit subsequent to screening, or were lost to f
D ,25 years (7.1 per 100 person-years) and the lowest rate among participants aged 40 years (1.6 per 100 person-years; P trend = 0.001). Country of residence was also associated with HSV-2 incidence, with theDaily Oral FTC/TDF PrEP and HSV-2 among MSMthere were 72 ulcer AEs classified as Grade 2 or above, with 43 participants (4.3 ) having 1 ulcer AE. Among the 72 ulcer AEs, 23 (31.9 ) were conf
N of cRAI in the past three months being reported more frequently in the placebo arm (P = 0.01). Of the 1,383 participants who tested seronegative for HSV-2 at baseline, 36 (2.6 ) did not contribute person-time to incidence analyses because they were retrospectively found to be HIVinfected at baseline, tested seropositive for HSV-2 at the enrollment visit subsequent to screening, or were lost to f
Nversion to determine whether there were differences in ulcer occurrence by randomization group in the absence of study drug. All analyses were conducted in SAS 9.3 or Stata 12.Results Study participantsCharacteristics of the 2,499 iPrEx participants have been described previously. [13] Briefly, all participants were born male and 313 (13.0 ) identified as transgender or as women. The mean age at
D ,25 years (7.1 per 100 person-years) and the lowest rate among participants aged 40 years (1.6 per 100 person-years; P trend = 0.001). Country of residence was also associated with HSV-2 incidence, with theDaily Oral FTC/TDF PrEP and HSV-2 among MSMthere were 72 ulcer AEs classified as Grade 2 or above, with 43 participants (4.3 ) having 1 ulcer AE. Among the 72 ulcer AEs, 23 (31.9 ) were conf
Ccuracy or low sensitivity for HSV-2 recurrences, and we were not able to use HSV PCR to confirm that ulcers were herpetic. Finally, AEs only captured ulcers that increased in severity or frequency; thus, the reduction in ulcers associated with FTC/TDF may have been greater than what we observed.Daily Oral FTC/TDF PrEP and HSV-2 among MSMFigure 2. Probability of testing HSV-2 seronegative by rando
Archal system in Nigeria [13], often in juxtaposition in the form of matricentric structures [14], patriarchy remains the dominant ideology [15]. Furthermore, a recent United Nations Development report shows that gender inequality in Nigeria is fuelled by socio-cultural practices, patriarchy among other reasons [16]. The patriarchal system in Nigeria uses inheritance customs to place women at a re
Archal system in Nigeria [13], often in juxtaposition in the form of matricentric structures [14], patriarchy remains the dominant ideology [15]. Furthermore, a recent United Nations Development report shows that gender inequality in Nigeria is fuelled by socio-cultural practices, patriarchy among other reasons [16]. The patriarchal system in Nigeria uses inheritance customs to place women at a re