Eptors. DC-SCRIPT is in this respect a unique co-regulator as we have shown that it enhances the activities of the nuclear retinoic acid receptor (RAR) and peroxisome proliferatoractivated receptor (PPAR) heterodimers, RARa/RXRa?2010 Sieuwerts et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creative
Inter-quartile after normalization on the reference gene set. cP for Spearman rank correlation test. dP for Mann-Whitney U test. eP for Kruskal-Wallis test, including a Wilcoxon-type test for trend when appropriate. fWith quantitative polymerase chain reaction cut point for positive versus negative ESR1 and PGR, 0.2 and 0.1, respectively, and for ESR2 at the median level of 0.005 (mRNA levels rela
Rogen receptor predict response to tamoxifen treatment in patients with recurrent breast cancer: a retrospective study. Clin Cancer Res 2005, 11:7311-7321. 17. Dorssers LC, van Agthoven T, Brinkman A, Veldscholte J, Smid M, Dechering KJ: Breast cancer oestrogen independence mediated by BCAR1 or BCAR3 genes is transmitted through mechanisms distinct from the oestrogen receptor signalling pathway or
Of DC-SCRIPT are associated with reduced tumor aggressiveness. The association is particularly strong for small tumors with high ESR1 or low ESR2 mRNA levels or both. Finally, although DC-SCRIPT negatively regulates ESR1 and PGR activity, DC-SCRIPT levels measured in theSieuwerts et al. Breast Cancer Research 2010, 12:R103 http://breast-cancer-research.com/content/12/6/RPage 9 ofprimary tumors are
Istance, metabolic syndrome, and breast cancer recurrence: a cohort studySang Woo Oh1*, Cheol-Young Park2, Eun Sook Lee3, Yeong Sook Yoon4, Eon Sook Lee4, Sang Shin Park1,5, Yuil Kim1, Nak Jin Sung1, Young Ho Yun6, Keun Seok Lee7, Han Sung Kang7, Youngmee Kwon7 and Jungsil Ro7*AbstractIntroduction: Several in vitro studies have suggested the effects of adipokines and insulin resistance on breast c
Istance, metabolic syndrome, and breast cancer recurrence: a cohort studySang Woo Oh1*, Cheol-Young Park2, Eun Sook Lee3, Yeong Sook Yoon4, Eon Sook Lee4, Sang Shin Park1,5, Yuil Kim1, Nak Jin Sung1, Young Ho Yun6, Keun Seok Lee7, Han Sung Kang7, Youngmee Kwon7 and Jungsil Ro7*AbstractIntroduction: Several in vitro studies have suggested the effects of adipokines and insulin resistance on breast c
Receptor modulation and prognostic significance in primary breast cancer. J Natl Cancer Inst 2010, 102:54-68. 8. Ramadoss P, Marcus C, Perdew GH: Role of the aryl hydrocarbon receptor in drug metabolism. Expert Opin Drug Metab Toxicol 2005, 1:9-21. 9. Osborne CK, Schiff R, Fuqua SA, Shou J: Estrogen receptor: current understanding of its activation and modulation. Clin Cancer Res 2001, 7:4338s-434
Receptor modulation and prognostic significance in primary breast cancer. J Natl Cancer Inst 2010, 102:54-68. 8. Ramadoss P, Marcus C, Perdew GH: Role of the aryl hydrocarbon receptor in drug metabolism. Expert Opin Drug Metab Toxicol 2005, 1:9-21. 9. Osborne CK, Schiff R, Fuqua SA, Shou J: Estrogen receptor: current understanding of its activation and modulation. Clin Cancer Res 2001, 7:4338s-434