Glycans (GAG) heparan sulfates, we assessed the role of plant lectins on the attachment of X4-tropic viruses, known to interact very efficiently with heparan sulfate [11] and data not shown]. Thus, cells were incubated with HIV-1NDK (Fig. 2B) in the presence or absence of different concentrations of HHA and GNA. As depicted in Figure 2B, none of the plant lectins, whatever the concentration, inhib
Bit Ability ofepithelial cells attachment of HIV-1 cell-free parAbility of lectins to inhibit attachment of HIV-1 cell-free particles on epithelial cells. HEC-1A cells were co-incubated with non-toxic concentrations of each lectins or mannan (100 /ml) and 5 ng of HIV-1Ba-L (A) or HIV-1NDK (B) virus were added for 1 h. Incubation with mannan was used as control. The quantity of attached virus was