R (1.825 and 6.446 g/ml) and were also in the same range as the IC80 values determined in vitro. It is worth noting that three of the six recipients of the 10-1074 MAb experienced rapid decay of plasma antibody, which fell to background levels between weeks 4 to 6 following administration (Fig. 3c). A similar pattern occurred for three of the 3BNC117 MAb and VRC01-LS recipients, although the decli
R (1.825 and 6.446 g/ml) and were also in the same range as the IC80 values determined in vitro. It is worth noting that three of the six recipients of the 10-1074 MAb experienced rapid decay of plasma antibody, which fell to background levels between weeks 4 to 6 following administration (Fig. 3c). A similar pattern occurred for three of the 3BNC117 MAb and VRC01-LS recipients, although the decli
Virus acquisition for VRC01 and VRC01-LS were superimposed on one another even though VRC01-LS had a longer half-life in vivo. In this same analysis, the curves for 10-1074 and 3BNC117, which conferred lower probabilities for infection at eachAuthor Manuscript Author Manuscript Author Manuscript Author ManuscriptNature. Author manuscript; available in PMC 2016 November 29.Gautam et al.Pageplasma M
O two comparable criteria: an epidemiologic efficiency criterion and an equity criterion.Efficiency criterionWe look at the effect over a year of the MC intervention on the male population, by calculating the risk of a man Rm getting infected by his female partner. This allows us to use a static model of transmission. The model does not look at the effect on the female population as there is not y
O two comparable criteria: an epidemiologic efficiency criterion and an equity criterion.Efficiency criterionWe look at the effect over a year of the MC intervention on the male population, by calculating the risk of a man Rm getting infected by his female partner. This allows us to use a static model of transmission. The model does not look at the effect on the female population as there is not y
O two comparable criteria: an epidemiologic efficiency criterion and an equity criterion.Efficiency criterionWe look at the effect over a year of the MC intervention on the male population, by calculating the risk of a man Rm getting infected by his female partner. This allows us to use a static model of transmission. The model does not look at the effect on the female population as there is not y
Ction conferred by Hepatitis A immune globulin, we tested the efficacy of a single injection (20mg/kg) of four anti-HIV-1 neutralizing monoclonal antibodies (MAbs) (VRC01, VRC01-LS, 3BNC117, and 10-10749-12) in blocking repeated weekly low dose virus challenges of the clade B SHIVAD8. Compared to control animals, which required 2 to 6 challenges (median=3 weeks) for infection, a single bNAb infusi
T the level of gene expression act cooperatively to establish and maintain HIV latency. In conclusion, our study reveals that TI represents a key mechanism that antagonizes proviral gene expression to promote the latency of HIV. Furthermore, it demonstrates several means that could be used to counteract TI for reactivating latent HIV. Future mechanistic studies linking TI and other transcriptional