Ed two models. Model 1 was constructed using variables with P
Test for trends. The Cox proportional hazards regression model was used to control for multiple factors simultaneously and to estimate adjusted hazard ratios (HRs) and 95 confidence intervals. The relative increase in the risk of breast cancer recurrence for each of the three higher quartiles was estimated in comparison to that for the lowest quartile; it was also used to test for a linear trend
D methods. A word file containing additional Materials and methods [25-28]. Additional file 2: Figure S1 - DC-SCRIPT mRNA expression in breast cancer subtypes. The box-plot shows the five statistics (lower whisker is 5 minimum, lower box part is 25th percentile, solid line in box presents the median, upper box part is 75th percentile and upper whisker is 95 maximum). Figure depicts P for Mann-Wh
D methods. A word file containing additional Materials and methods [25-28]. Additional file 2: Figure S1 - DC-SCRIPT mRNA expression in breast cancer subtypes. The box-plot shows the five statistics (lower whisker is 5 minimum, lower box part is 25th percentile, solid line in box presents the median, upper box part is 75th percentile and upper whisker is 95 maximum). Figure depicts P for Mann-Wh
Receptor modulation and prognostic significance in primary breast cancer. J Natl Cancer Inst 2010, 102:54-68. 8. Ramadoss P, Marcus C, Perdew GH: Role of the aryl hydrocarbon receptor in drug metabolism. Expert Opin Drug Metab Toxicol 2005, 1:9-21. 9. Osborne CK, Schiff R, Fuqua SA, Shou J: Estrogen receptor: current understanding of its activation and modulation. Clin Cancer Res 2001, 7:4338s-434
Receptor modulation and prognostic significance in primary breast cancer. J Natl Cancer Inst 2010, 102:54-68. 8. Ramadoss P, Marcus C, Perdew GH: Role of the aryl hydrocarbon receptor in drug metabolism. Expert Opin Drug Metab Toxicol 2005, 1:9-21. 9. Osborne CK, Schiff R, Fuqua SA, Shou J: Estrogen receptor: current understanding of its activation and modulation. Clin Cancer Res 2001, 7:4338s-434
Of DC-SCRIPT are associated with reduced tumor aggressiveness. The association is particularly strong for small tumors with high ESR1 or low ESR2 mRNA levels or both. Finally, although DC-SCRIPT negatively regulates ESR1 and PGR activity, DC-SCRIPT levels measured in theSieuwerts et al. Breast Cancer Research 2010, 12:R103 http://breast-cancer-research.com/content/12/6/RPage 9 ofprimary tumors are
Of DC-SCRIPT are associated with reduced tumor aggressiveness. The association is particularly strong for small tumors with high ESR1 or low ESR2 mRNA levels or both. Finally, although DC-SCRIPT negatively regulates ESR1 and PGR activity, DC-SCRIPT levels measured in theSieuwerts et al. Breast Cancer Research 2010, 12:R103 http://breast-cancer-research.com/content/12/6/RPage 9 ofprimary tumors are