Th the 10-1074 MAb, the median number of challenges for successful infection in the three-animal subgroup not experiencing the rapid anti-antibody induced decay, was 17.0 weeks compared to 12.5 for the entire 10-1074 recipient cohort. Probit analysis was also used to estimate the probability of infection as a function of the imputed plasma MAb concentration at the time of each challenge. The proba
Th the 10-1074 MAb, the median number of challenges for successful infection in the three-animal subgroup not experiencing the rapid anti-antibody induced decay, was 17.0 weeks compared to 12.5 for the entire 10-1074 recipient cohort. Probit analysis was also used to estimate the probability of infection as a function of the imputed plasma MAb concentration at the time of each challenge. The proba
O two comparable criteria: an epidemiologic efficiency criterion and an equity criterion.Efficiency criterionWe look at the effect over a year of the MC intervention on the male population, by calculating the risk of a man Rm getting infected by his female partner. This allows us to use a static model of transmission. The model does not look at the effect on the female population as there is not y
Ns dormant. In contrast, we demonstrated that TI could be counteracted by specific inhibition of the upstream transcription or by cooperative activation of transcription initiation and elongation from the 5'LTR by the viral and host TFs. In the latter scenario, we envision that RNAPII initiating from the viral promoter competes successfully with the RNAPII that is elongating through the 5'LTR. Bec
Intrarectal (IR) route with 10 TCID50 of SHIVAD8-EO, in the absence of antibody treatment. As shown in Fig. 1a, plasma viremia became detectable following 2 to 6 challenges, with a median of 3.0 weekly virus exposures needed to infect all nine animals. Based on these results, the inoculum size administered to each monkey per challenge was estimated to be 0.27 AID50. The regimen used to assess the
Intrarectal (IR) route with 10 TCID50 of SHIVAD8-EO, in the absence of antibody treatment. As shown in Fig. 1a, plasma viremia became detectable following 2 to 6 challenges, with a median of 3.0 weekly virus exposures needed to infect all nine animals. Based on these results, the inoculum size administered to each monkey per challenge was estimated to be 0.27 AID50. The regimen used to assess the
O two comparable criteria: an epidemiologic efficiency criterion and an equity criterion.Efficiency criterionWe look at the effect over a year of the MC intervention on the male population, by calculating the risk of a man Rm getting infected by his female partner. This allows us to use a static model of transmission. The model does not look at the effect on the female population as there is not y
Hments of PS5-RNAPII upon TNF- treatment (25-fold and 80-fold, respectively; Figure 5E, bars 4 and 8). Predictably, about 6-fold and 8-fold enrichment of RNAPII and PS2-RNAPII was observed at the PP5*/5'LTR junction in unstimulated cells (Figure 5C, bars 1 and 2), which was slightly decreased in TNF--treated cells (Figure 5D, bars 1 and 2). A minimal (2-3-fold) enrichment of RNAPII as well as its