Ategories. Patients having ER-negative and PR-negative was designated as the ER/PR-negative group, and ER-positive or PR-positive as the ER/PR-positive group. Because significant interactions were observed between ER/PR status and the primary measures, and because the use of adjuvant endocrine therapy and prognosis varies according to ER/PR receptor status, we analyzed data according to ER/PR-posi
F 1.9 . The homeostasis model assessment for insulin resistance (HOMA-IR) was used to estimate insulin resistance as determined by the following formula: ((fasting insulin (U/mL) ?fasting glucose (mmol/liter))/22.5 [24]. Serum estradiol was measured using an electrochemiluminescence immunoassay analyzer (Roche Modular Analytics E170; Roche, Mannheim, Germany) with a CV of 2.4 . Serum adiponectin l
F 1.9 . The homeostasis model assessment for insulin resistance (HOMA-IR) was used to estimate insulin resistance as determined by the following formula: ((fasting insulin (U/mL) ?fasting glucose (mmol/liter))/22.5 [24]. Serum estradiol was measured using an electrochemiluminescence immunoassay analyzer (Roche Modular Analytics E170; Roche, Mannheim, Germany) with a CV of 2.4 . Serum adiponectin l
Omly assigned patients among treated and untreatedSieuwerts et al. Breast Cancer Research 2010, 12:R103 http://breast-cancer-research.com/content/12/6/RPage 8 ofFigure 1 Metastasis-free survival as a function of dichotomized DC-SCRIPT. Metastasis-free survival is shown as a function of dichotomized DC-SCRIPT in 837 lymph-node negative, primary breast cancer patients after subdividing them accordin
Omly assigned patients among treated and untreatedSieuwerts et al. Breast Cancer Research 2010, 12:R103 http://breast-cancer-research.com/content/12/6/RPage 8 ofFigure 1 Metastasis-free survival as a function of dichotomized DC-SCRIPT. Metastasis-free survival is shown as a function of dichotomized DC-SCRIPT in 837 lymph-node negative, primary breast cancer patients after subdividing them accordin
Omly assigned patients among treated and untreatedSieuwerts et al. Breast Cancer Research 2010, 12:R103 http://breast-cancer-research.com/content/12/6/RPage 8 ofFigure 1 Metastasis-free survival as a function of dichotomized DC-SCRIPT. Metastasis-free survival is shown as a function of dichotomized DC-SCRIPT in 837 lymph-node negative, primary breast cancer patients after subdividing them accordin
Nd multivariable analysis higher DC-SCRIPT levels were associated with a favorable outcome for both the entire cohort and patients with lymph node-negative (LNN) disease that did not receive adjuvant therapy (DFS, MFS and OS; all, P
Either ESR1-positive and/or ESR2-low pT1 tumors.Introduction Estrogens influence the aggressiveness of breast cancer through their cognate nuclear receptors. In particular, the estrogen receptor-alpha (ERa) (ESR1) - present in tumor cells of about 70 to 75 of all breast tumors is considered crucial because of its proliferationinducing actions and for that reason is an important target for therap