Nks.lww.com/QAD/A400). Similarly, when comparing `Xpert plus LF-LAM' with `Xpert' testing alone, there were few circumstances in which `Xpert/LF-LAM' algorithm was not considered highly cost-effective. The ICER comparing `Xpert plus LF-LAM' algorithm with `Xpert' was most influenced by the specificity of LF-LAM and lifeexpectancy after TB treatment, but remained cost-effective even at lowest estim
N among people living with HIV in Uganda remains low, with many health centers relying upon smear-microscopy as the primary diagnostic tool. Our study suggests that for HIV-infected individuals meeting WHO symptom screening criteria for TB evaluation, a diagnostic algorithm utilizing the combination of rapid point-of-care urine LFLAM and sputum Xpert testing would be considered highly cost-effecti
E cost of TB diagnostic testing comprised less than 0.01 of total costs per person when HIV/ART care was considered for all diagnostic algorithms. Cost-effectiveness of tuberculosis diagnostic algorithms Compared with the reference `Smear' algorithm, all algorithms incorporating rapid diagnostic testing with Xpert and/or LF-LAM were considered highly cost-effective at a willingness to pay thresho
Of smear-microscopy alone for evaluation of HIV-patients with signs/symptoms of TB. Overall, we found that incorporation of both LF-LAM and Xpert into TB case-finding algorithms represented excellent value for money for HIV and TB programs. The ICER for this rapid `Xpert plus LF-LAM' diagnostic intervention ( 57/DALY-averted) compares favorably to other HIV-care interventions in Uganda such as com
In part, the evolutionary selection of MBL mutant haplotypes that encode low or intermediate MBL serum levels in the majority of humans.Supporting InformationFigure S1 RhMBL enhances HIV-EBOV GP infection in a calcium-dependent manner. We preincubated HIVEBOV-GP virion-like particles with rhMBL in 5 MBL-deficient serum and Veronal-buffered saline with or without calcium supplementation. *, ** and
In part, the evolutionary selection of MBL mutant haplotypes that encode low or intermediate MBL serum levels in the majority of humans.Supporting InformationFigure S1 RhMBL enhances HIV-EBOV GP infection in a calcium-dependent manner. We preincubated HIVEBOV-GP virion-like particles with rhMBL in 5 MBL-deficient serum and Veronal-buffered saline with or without calcium supplementation. *, ** and
In part, the evolutionary selection of MBL mutant haplotypes that encode low or intermediate MBL serum levels in the majority of humans.Supporting InformationFigure S1 RhMBL enhances HIV-EBOV GP infection in a calcium-dependent manner. We preincubated HIVEBOV-GP virion-like particles with rhMBL in 5 MBL-deficient serum and Veronal-buffered saline with or without calcium supplementation. *, ** and
In part, the evolutionary selection of MBL mutant haplotypes that encode low or intermediate MBL serum levels in the majority of humans.Supporting InformationFigure S1 RhMBL enhances HIV-EBOV GP infection in a calcium-dependent manner. We preincubated HIVEBOV-GP virion-like particles with rhMBL in 5 MBL-deficient serum and Veronal-buffered saline with or without calcium supplementation. *, ** and