Ption were detected. All analyses were performed with Stata version 10.1 (StataCorp, College Station, TX, USA). A two-sided P-value
Ption were detected. All analyses were performed with Stata version 10.1 (StataCorp, College Station, TX, USA). A two-sided P-value
Ed two models. Model 1 was constructed using variables with P
Ed two models. Model 1 was constructed using variables with P
Their advanced disease and therefore was better suited to study a putative relation of DC-SCRIPT and response to therapy. Despite the positive association of DC-SCRIPT with ESR1, DC-SCRIPT levels were unable to identify patients with ESR1-positive primary tumors at high or low risk to progress if treated with tamoxifen. Thus, although DC-SCRIPT can modulate the activity of ESR1, it does not affect
Receptor modulation and prognostic significance in primary breast cancer. J Natl Cancer Inst 2010, 102:54-68. 8. Ramadoss P, Marcus C, Perdew GH: Role of the aryl hydrocarbon receptor in drug metabolism. Expert Opin Drug Metab Toxicol 2005, 1:9-21. 9. Osborne CK, Schiff R, Fuqua SA, Shou J: Estrogen receptor: current understanding of its activation and modulation. Clin Cancer Res 2001, 7:4338s-434
Rogen receptor predict response to tamoxifen treatment in patients with recurrent breast cancer: a retrospective study. Clin Cancer Res 2005, 11:7311-7321. 17. Dorssers LC, van Agthoven T, Brinkman A, Veldscholte J, Smid M, Dechering KJ: Breast cancer oestrogen independence mediated by BCAR1 or BCAR3 genes is transmitted through mechanisms distinct from the oestrogen receptor signalling pathway or
Either ESR1-positive and/or ESR2-low pT1 tumors.Introduction Estrogens influence the aggressiveness of breast cancer through their cognate nuclear receptors. In particular, the estrogen receptor-alpha (ERa) (ESR1) - present in tumor cells of about 70 to 75 of all breast tumors is considered crucial because of its proliferationinducing actions and for that reason is an important target for therap