Technology for inferring co-receptor usage in HIV-1. PLoS ONE 9, e99508 (2014). 11. Kagan, R. M. et al. A genotypic test for HIV-1 tropism combining Sanger sequencing with ultradeep sequencing predicts virologic response in treatment-experienced patients. PLoS ONE 7, e46334 (2012). 12. Gibson, R. M. et al. Sensitive deep-sequencing-based HIV-1 genotyping assay to simultaneously determine susceptib
S were found to have similar or higher efficacy based on the effective drug concentration resulting in 10-fold reduction of RT activity (EC90). On average, 5-fold higher therapeutic levels of nanodrugs compared to EC90 levels observed in the infected MDM could be reached in the brain even 24h after the systemic administration of BP2-NG/NTP. The reported here nano-NRTI approach is the further step
These are several that target sites on the HIV that are exposed only after the virus has attached to a cell. These antibodies have a brief window of time to prevent fusion of the virus and cell. They are special in that they bind both to the viral membrane and to sequences on the gp41 protein that lie along the viral surface. Here, we present a model that predicts the concentrations at which these
These are several that target sites on the HIV that are exposed only after the virus has attached to a cell. These antibodies have a brief window of time to prevent fusion of the virus and cell. They are special in that they bind both to the viral membrane and to sequences on the gp41 protein that lie along the viral surface. Here, we present a model that predicts the concentrations at which these
These are several that target sites on the HIV that are exposed only after the virus has attached to a cell. These antibodies have a brief window of time to prevent fusion of the virus and cell. They are special in that they bind both to the viral membrane and to sequences on the gp41 protein that lie along the viral surface. Here, we present a model that predicts the concentrations at which these
Nts in clinical practice but technical optimization are needed to improve quantification. Human immunodeficiency virus (HIV) enters its host cells following the interaction between the virus envelope glycoprotein (Gp120), the cell surface CD4 receptor, and a chemokine receptor, which may be CCR5 and/ or CXCR4, acting as a coreceptor1. The HIV tropism is defined by the coreceptor(s) use and is corr
Anti-HIV therapeutic levels in the CNS.NIH-PA Author Manuscript NIH-PA Author Manuscript NIH-PA Author ManuscriptDISCUSSIONEffective CNS delivery of many drugs, especially hydrophilic and negatively charged molecules, still remains an unsolved dilemma. Progress of nanotechnology and development of novel particulate drug delivery systems resulted in the extensive search for drug nanoformulations th
Anti-HIV therapeutic levels in the CNS.NIH-PA Author Manuscript NIH-PA Author Manuscript NIH-PA Author ManuscriptDISCUSSIONEffective CNS delivery of many drugs, especially hydrophilic and negatively charged molecules, still remains an unsolved dilemma. Progress of nanotechnology and development of novel particulate drug delivery systems resulted in the extensive search for drug nanoformulations th